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Description
A condition in which greater-than-normal amounts of cholesterol are present in the blood.
Toxic Effects of Excess Cholesterol
Oxidized Low Density Lipoproteins (LDL) Cholesterol is responsible for most of Cholesterol's toxic effects.
Elevated serum Cholesterol is known medically as Hypercholesterolemia.
Cardiovascular System
Oxidized Cholesterol in Low Density Lipoproteins is a component of the deposits (plaques) formed in the Arteries implicated in Atherosclerosis.
Elevated serum Cholesterol increases the "stickiness" of the Platelets in the Blood - contributing to Blood Clots.
Excess Cholesterol can be deposited around Cardiac Muscle - Homocysteine facilitates this deposition.
Elevated serum Cholesterol increases the risk of Heart Attack (as a consequence of elevated Cholesterol’s role in Atherosclerosis). Every 1% reduction in total Cholesterol levels produces a 2% reduction in the risk for (fatal or nonfatal) Heart Attack.
Digestive System
Excessive Cholesterol can cause Gallstones - if the Phosphatidylcholine:Cholesterol ratio of Bile decreases, the risk of Gallstones increases.
Hair
Cholesterol is the starting point in the long biochemical pathway that leads to the formation of 5-Alpha Reductase enzyme that converts Testosterone to Dihydrotestosterone - the substance implicated in Male Pattern Baldness:
- Male Pattern Baldness sufferers are more likely to exhibit elevated total serum Cholesterol levels than those who are not afflicted with MPB.
Immune System
Excessive dietary Cholesterol is implicated in Lung Cancer.
Substances that Minimize the Toxic Effects of Cholesterol
Lipids
Conjugated Linoleic Acid (CLA) increases the stability of Cholesterol, making it less susceptible to Oxidation.
Vitamins
Vitamin C prevents the incorporation of Cholesterol into atherosclerotic plaque that is integral to the development of Atherosclerosis (i.e. Vitamin C ensures that Cholesterol remains within the bloodstream rather than affixed to Artery Walls).
Substances that Exacerbate the Toxic Effects of Cholesterol
Lipids
EXCESSIVE Linoleic Acid increases the susceptibility of Cholesterol to Oxidation.
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